8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Apr 4th 2026
ReturnsSun, Apr 12th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis… 
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Apr 11th 2026
ReturnsSun, Apr 19th 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Apr 18th 2026
ReturnsSun, Apr 26th 2026
Nights8
Departing PortNew Orleans
Ports of CallNew Orleans, Mississippi River, Oak Alley, St. Francisville, Natchez, Vicksburg, Cleveland, Memphis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
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Suite
Call for pricing
8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Apr 25th 2026
ReturnsSun, May 3rd 2026
Nights8
Departing PortMemphis
Ports of CallMemphis, Mississippi River, Cleveland, Vicksburg, Natchez, St. Francisville, Cruising the River, Oak Alley, New Orleans
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Ocean View
Call for pricing
Balcony
Call for pricing
Suite
Call for pricing
Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
